Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:13838
  • Symbol:Epha4
  • Description:Eph receptor A4
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Gene ID Entry Entry Name Protein Name Type Information
13838 Q03137 EPHA4_MOUSE Ephrin type-A receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor MPK-3) (Tyrosine-protein kinase receptor SEK-1) DISRUPTION PHENOTYPE Mice are viable and fertile but display a loss of coordination of limb movement associated with disruptions of cortico-spinal tract. They also display altered development of the thymic epithelium which leads to a defective T-cells development. {ECO:0000269|PubMed:15537875, ECO:0000269|PubMed:16818734, ECO:0000269|PubMed:9789074}.