| 13846 | P54761 | EPHB4_MOUSE | Ephrin type-B receptor 4 (EC 2.7.10.1) (Developmental kinase 2) (mDK-2) (Hepatoma transmembrane kinase) (Tyrosine kinase MYK-1) | DISRUPTION PHENOTYPE | Embryo display cardiovascular defects and lethality with very high penetrance. Growth retardation is observed at 9.5 dpc with arrested heart development and lack of blood flow. By 10.5 dpc degeneration and necrosis are apparent throughout the embryo. Conditional lymphovenous valves knockouts show a complete loss of lymphatic valves (PubMed:27400125). {ECO:0000269|PubMed:10518221, ECO:0000269|PubMed:27400125}. |