| 14083 | P34152 | FAK1_MOUSE | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | DISRUPTION PHENOTYPE | Embryonically lethal. Embryos die at about 8.5 dpc, despite normal implantation. Embryos do not develop a normal head fold, neural tube or heart tube. Endothelial-specific gene disruption is lethal at about 11 dpc, due to defects in embryonic angiogenesis. {ECO:0000269|PubMed:15967814, ECO:0000269|PubMed:16391003, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:7478517}. |