| 14118 | Q61554 | FBN1_MOUSE | Fibrillin-1 [Cleaved into: Asprosin] | DISRUPTION PHENOTYPE | Neonatal lethality due to ruptured aortic aneurysm, impaired pulmonary function and/or diaphragmatic collapse. Neonatal aorta show a disorganized and poorly developed medial layer but normal levels of elastin cross-links. {ECO:0000269|PubMed:16407178}.; DISRUPTION PHENOTYPE: [Asprosin]: Mice lacking Asprosin show low appetite, reduced adiposity and protection from diet-induced obesity. {ECO:0000269|PubMed:29106398}. |