| 14119 | Q61555 | FBN2_MOUSE | Fibrillin-2 [Cleaved into: Placensin] | DISRUPTION PHENOTYPE | Limb-patterning defects characterized by bilateral syndactyly due to disorganized matrix (PubMed:11470817). Digit fusion involves both soft and hard tissues and is associated with reduced apoptosis at affected sites (PubMed:11470817). Mice show a well developed and morphologically normal aortic wall (PubMed:16407178). Mice display a low bone mass phenotype that is associated with reduced bone formation (PubMed:20855508). {ECO:0000269|PubMed:11470817, ECO:0000269|PubMed:16407178, ECO:0000269|PubMed:20855508}. |