| 14129 | P26151 | FCGR1_MOUSE | High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (CD antigen CD64) | DISRUPTION PHENOTYPE | According to PubMed:11911823, mice display altered endocytosis of monomeric IgG and impaired antibody-dependent killing of cells by macrophage. Antigen presentation is also affected and those mice develop only reduced inflammatory responses. An increased in IgG responses is also detected associated with an increased number of antibody-forming cells. PubMed:11911824, also reported that a variety of IgG2a-immune complex-dependent immune functions like protection against bacterial infection were impaired. {ECO:0000269|PubMed:11911823, ECO:0000269|PubMed:11911824}. |