| 14254 | P35969 | VGFR1_MOUSE | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT) | DISRUPTION PHENOTYPE | Embryonic lethality at about 9 dpc, due to defects in the formation and organization of the vascular network (PubMed:7596436, PubMed:9689083). Mice display abnormal blood island structures in the yolk sac, leading to defects in the organization of the vascular endothelium, excess growth and disorganization of embryonic and extraembryonic vasculature, including the endocardium and the microvasculature (PubMed:7596436). Reduced vascular sprout formation and migration (PubMed:14982871). Loss of retinal hyaloid vessel regression from postnatal day 3 (P3) to P8 (PubMed:30936473). Mice expressing a mutant protein that lacks the kinase domain survive and have no apparent phenotype (PubMed:9689083). {ECO:0000269|PubMed:14982871, ECO:0000269|PubMed:30936473, ECO:0000269|PubMed:7596436, ECO:0000269|PubMed:9689083}. |