| 14368 | Q61089 | FZD6_MOUSE | Frizzled-6 (Fz-6) (mFz6) | DISRUPTION PHENOTYPE | Half of the males without the gene, but not females, display abnormal claw morphology or absent claws compared to wild-type; at the age of 2 to 3 months, the claws disappear or become rudimentary on the hind limbs (PubMed:21665003). FZD3 and FZD6 double knockout embryos have a curled tail, exhibit defects in neural tube and eyelids closure, in the orientation of hair bundles on inner-ear sensory cells and die at birth (PubMed:16495441). {ECO:0000269|PubMed:16495441, ECO:0000269|PubMed:21665003}. |