| 14527 | Q61606 | GLR_MOUSE | Glucagon receptor (GL-R) | DISRUPTION PHENOTYPE | Mice are born at the expected Mendelian rate. They display pancreas islet and alpha-cell hyperplasia and increased glucagon levels, but normal insulin levels. Mice display low blood glucose levels combined with increased hepatic glycogen levels. They develop severe hypoglycemia after prolonged fasting. Mutant mice are fertile, but the females produce only few pups; half of the embryos die before birth, and liveborn pups do not survive more than one day. These pups are much smaller than their littermates and exhibit severe hypoglycemia. {ECO:0000269|PubMed:12552113, ECO:0000269|PubMed:16627579, ECO:0000269|PubMed:19046568}. |