Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:14664
  • Symbol:Slc6a9
  • Description:solute carrier family 6 (neurotransmitter transporter, glycine), member 9
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Gene ID Entry Entry Name Protein Name Type Information
14664 P28571 SC6A9_MOUSE Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) DISRUPTION PHENOTYPE Mice show severe motor and respiration deficits at birth and die during the first postnatal day (PubMed:14622582). Accumulation of glycine in the synaptic cleft results in over-activation of postsynaptic glycine receptors and death of the newborn animals due to respiratory and feeding problem (PubMed:14622582). {ECO:0000269|PubMed:14622582}.