| 14745 | P61793 | LPAR1_MOUSE | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) (Rec1.3) (VZG-1) | DISRUPTION PHENOTYPE | Mutant embryos are detected at the expected Mendelian rate, but there is about 50% perinatal lethality. This is mostly due to suckling defects, possibly because the neonates cannot find a nipple. Surviving mice are smaller, and they have shorter snouts and more widely spaced eyes than wild-type. A small percentage of the embryos and neonates display frontal hematomas. Besides, a small percentage of the embryos display exencephaly (PubMed:11087877). These mice display also deformity of the rib cage with sterno-distal rib fusions, shorter, crooked sternebrae, delayed vertebral calcification and closure of the thoracic spine (PubMed:21569876). Their small size is due to growth defects of limbs and vertebrae (PubMed:21569876). Mutant mice display decreased bone mass, as well as defects in proliferation and osteoblastic differentiation of bone marrow mesenchymal stem cells (PubMed:21569876). A spontaneous variant (the Malaga variant) that appeared among the descendants of the original knockout mice shows almost complete perinatal viability, but the mice still present small size, shorter snouts, wider-spaced eyes and reduced brain volume (PubMed:17656621). Compared to wild-type, the Malaga variants display smaller olfactory bulbs, and generally a smaller brain with slightly decreased thickness of the brain cortex and subtle defects in cortex development (PubMed:17656621). The hippocampus appears normal at birth, but displays a reduced number of cell divisions in adult dentate gyrus, both under normal conditions and when mice are exposed to a stimulating environment that promotes neurogenesis (PubMed:18708146). Compared to wild-type, the newly formed hippocampus cells show reduced survival (PubMed:18708146). Newly formed granule cells display defects in their maturation (PubMed:18708146). Mutant mice present subtle myelination defects in the brain cortex (PubMed:25226845). Mutant mice display minor defects in somesthesis, olfaction, grasping and keeping their equilibrium, and show decreased sensitivity to pain caused by heat (PubMed:19689455). Mutant mice do not display allodynia and hyperalgesia after nerve injury and are protected against demyelination after nerve injury (PubMed:15195086). Mutant mice display increased Schwann cell apoptosis in sciatic nerve, but this still leaves the majority of Schwann cells intact and does not cause any visible effect on movement (PubMed:11087877). Mutant mice display decreased exploration in the open field and increased anxiety-like responses to novelty; they also show subtle deficits in spatial learning and memory (PubMed:19689455). Mutant mice show blunted responses to bacterial lipopolysaccharide (LPS) and show reduced acute inflammation in response to LPS (PubMed:21821728). Mutant mice show decreased migration of fibroblasts to sites of lung injury, decreased injury-induced vascular leak, and are protected against the development of lung fibrosis after bleomycin treatment (PubMed:18066075). Mutant mice have reduced levels of proliferating epithelial cells in their intestinal crypts, and the cells do not migrate normally from the bottom of the crypts up into the villi (PubMed:23478264). Mutant mice show impaired repair after wounding of the intestinal mucosa (PubMed:23478264).Mutant mice have less body weight, but increased brown and white adipose tissue (PubMed:20358347). Contrary to wild-type, mutant mice do not increase their food consumption on a high fat diet and do not gain weight on a high fat diet (PubMed:20358347). Mice deficient in both Lpar1 and Lpar2 have the same phenotype as mice lacking Lpar1, excepting a higher incidence of frontal hematomas and slightly higher perinatal lethality (PubMed:12215548). {ECO:0000269|PubMed:11087877, ECO:0000269|PubMed:12215548, ECO:0000269|PubMed:15195086, ECO:0000269|PubMed:17656621, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:18708146, ECO:0000269|PubMed:19689455, ECO:0000269|PubMed:20358347, ECO:0000269|PubMed:21569876, ECO:0000269|PubMed:21821728, ECO:0000269|PubMed:25226845}. |