| 14748 | P35413 | GPR3_MOUSE | G-protein coupled receptor 3 (GPCR21) | DISRUPTION PHENOTYPE | Mice are fertile but display progressive reduction in litter size despite a stable age-independent alteration of the meiotic pause, characterized by premature resumption of meiosis in about one-third of antral follicles in mutant females regardless of age. Aging mutant mice had severe reduction of fertility, manifested by an increasing number of nondeveloping early embryos upon spontaneous ovulation and massive amounts of fragmented oocytes after superovulation. {ECO:0000269|PubMed:15956199}. |