Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:15183
  • Symbol:Hdac3
  • Description:histone deacetylase 3
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Gene ID Entry Entry Name Protein Name Type Information
15183 O88895 HDAC3_MOUSE Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) DISRUPTION PHENOTYPE Liver-specific knockout mice exhibit low amplitude of circadian rhythms, dampened E-box-driven transcription and a significant reduction in the protein levels of BMAL1 and CRY1 in the liver. {ECO:0000269|PubMed:26776516}.