| 15248 | Q9R1Y5 | HIC1_MOUSE | Hypermethylated in cancer 1 protein (Hic-1) | DISRUPTION PHENOTYPE | Impaired development resulting in embryonic and perinatal lethality (PubMed:10655551, PubMed:12539045). Serious developmental anomalies including acrania, exencephaly, cleft palate, omphalocele and limb abnormalities (PubMed:10655551). Mice disrupted in the germ line for only one allele of Hic1 develop many different spontaneous malignant tumors, including a predominance of epithelial cancers in males and lymphomas and sarcomas in females (PubMed:12539045). The complete loss of Hic1 function in the heterozygous mice seems to involve dense methylation of the promoter of the remaining wild-type allele (PubMed:12539045). {ECO:0000269|PubMed:10655551, ECO:0000269|PubMed:12539045}. |