| 15467 | Q9Z2R9 | E2AK1_MOUSE | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Hemin-sensitive initiation factor 2-alpha kinase) | DISRUPTION PHENOTYPE | Mice are viable and fertile without gross morphological abnormalities but display hyperchromic anemia in animals suffering from iron deficiency (PubMed:11726526). Dramatically altered response to diet-induced iron deficiency shifting from an adaptive decrease in red blood cells (RBCs) volume and intracellular hemoglobin content to an increased production of abnormally dense red blood cells (RBCs) with decreasing red cell counts (PubMed:11726526). The decrease in RBC number is the result of increased apoptosis of erythroid precursors (PubMed:11726526). Diminished levels of phosphorylated EIF2S1 in bone marrow-derived macrophages (BMDMs) (PubMed:17932563). Impaired maturation of BMDMs and blunted inflammatory response to LPS with a reduced cytokine production. Impaired phagocytosis of senescent RBCs by macrophages, resulting in a lower phagocytosis index and lower percentage of macrophages with ingested RBC (PubMed:17932563). {ECO:0000269|PubMed:11726526, ECO:0000269|PubMed:17932563, ECO:0000269|PubMed:20071449}. |