| 15551 | P28334 | 5HT1B_MOUSE | 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B) | DISRUPTION PHENOTYPE | Mutant male mice display increased aggressivity towards intruders. Treatment with a Htr1b agonist does not trigger increased locomotor behavior in mutant mice, contrary to what is observed with wild-type mice. Treatment with a Htr1b agonist does not inhibit 5-hydroxytryptamine release in the frontal cortex and hippocampus of mutant mice, contrary to what is observed with wild-type mice. Likewise, Htr1b agonists do not inhibit dopamine and acetylcholine release in brains from mutant mice. {ECO:0000269|PubMed:10651141, ECO:0000269|PubMed:16750486, ECO:0000269|PubMed:8091214, ECO:0000269|PubMed:8742487, ECO:0000269|PubMed:9349547}. |