| 15558 | P35363 | 5HT2A_MOUSE | 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) | DISRUPTION PHENOTYPE | Mutant mice display increased exploratory behavior in open spaces and reduced anxiety-like behavior (PubMed:16873667). Mutant mice fail to show behavorial responses to psychoactive substances and hallucinogens, such as mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane and lysergic acid diethylamide (LSD) (PubMed:17270739). Besides, the colon from mutant mice does not contract in response to 5-hydroxytryptamine (PubMed:11960784). {ECO:0000269|PubMed:11960784, ECO:0000269|PubMed:16873667, ECO:0000269|PubMed:17270739}. |