| 15560 | P34968 | 5HT2C_MOUSE | 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) | DISRUPTION PHENOTYPE | No obvious phenotype at birth, but mutant mice are prone to sudden death from seizures. When fed ad libitum, adult mice display higher body weight and increased adiposity compared to wild-type littermates. No difference in body weight is found when they receive the same amount of food as their wild-type littermates, indicating that the increased body weight is due to altered feeding behavior. Overweight older mice develop insulin resistance and impaired glucose tolerance. Young mice exhibit insulin resistance, but normal glucose tolerance, due to increased insulin levels in the blood. Insulin resistance is reversed when Htr2c expression is restored in pro-opiomelacortin neurons. Mutant mice display impaired activation of pro-opiomelacortin neurons in the paraventricular nucleus of the hypothalamus, leading to decreased release of CRH and corticosterone. Likewise, they exhibit blunted behavorial responses to anxiogenic environments and stress. {ECO:0000269|PubMed:17451451, ECO:0000269|PubMed:17596444, ECO:0000269|PubMed:19038216, ECO:0000269|PubMed:19501602, ECO:0000269|PubMed:21037584, ECO:0000269|PubMed:21048120, ECO:0000269|PubMed:21835345, ECO:0000269|PubMed:7700379, ECO:0000269|PubMed:9771748}. |