Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:15567
  • Symbol:Slc6a4
  • Description:solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
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Gene ID Entry Entry Name Protein Name Type Information
15567 Q60857 SC6A4_MOUSE Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) DISRUPTION PHENOTYPE Mutant mice are born at the expected Mendelian rate. Knockdown results in loss of serotonin uptake in synaptosomes of brainstem and cortex, abnormal barrel cortex development, enteric nervous system hyperplasia and reduced peristaltic reflexes. {ECO:0000269|PubMed:25600870, ECO:0000269|PubMed:27111230, ECO:0000269|PubMed:9547354}.