| 15572 | Q61701 | ELAV4_MOUSE | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | DISRUPTION PHENOTYPE | Transiently impaired neurite extensions of several cranial nerves, including glossopharyngeal nerve, hypoglossal nerve, trigeminal nerve and acousticofacial nerves in the midembryonic nervous system at 10.5 dpc, however no developmental delays of the nervous system in later-stage embryos at 14 dpc are obvious (PubMed:15764704). By postnatal weeks 4 to 8, 70-80% of the mice exhibit an abnormal clasping reflex of the hind limbs upon being suspended by the tail (PubMed:15764704). Decreased motor coordination, as impaired performance on an accelerating rotarod is observed (PubMed:15764704). Embryonic neural stem cells exhibit enhanced cell renewal capacity and decreased ability to differentiate into neurons (PubMed:15764704). Failure of neural progenitor cells to leave the cell cycle, resulting in increased apoptosis and in reduced production of postmitotic neurons (PubMed:15764704). Increased number of slowly dividing cells in the subventricular zone (PubMed:15764704). High insulin levels in pancreatic beta cells (PubMed:22387028). At 28 dpc, a decreased number of lower layer neocortical neurons is observed and lower layer neocortical neurons and CA3 hippocampal neurons exhibit a decreased dendritic complexity with fewer basal and apical branchpoints, fewer branch endings and shorter basal dendrites (PubMed:24599466). Basal branching deficiency in neocortical lower layer neurons and in hippocampal CA3 neurons persists into adulthood at 90 dpc (PubMed:24599466). Increased time spent in low-energy-expending activities and less in the high-energy activity of locomotion, indicating an anxiety response (PubMed:24599466). Decreased performance in finding a hidden platform in a water bath (Morris water maze test), suggesting difficulty in learning, lack of avoidance of the open arm in a elevated plus maze test, suggesting an aberrant response to anxiety-producing environments, and higher susceptibility to auditory-induced seizures (PubMed:24599466). RNAi-mediated knockdown in the neocortex at 13.5 dpc results in reduced neurite outgrowth (PubMed:24599466). RNAi-mediated knockdown in neural stem/progenitor cells in the adult subventricular zone impairs early neuronal differentiation (PubMed:26305964). {ECO:0000269|PubMed:15764704, ECO:0000269|PubMed:22387028, ECO:0000269|PubMed:24599466, ECO:0000269|PubMed:26305964}. |