| 16147 | P97812 | IHH_MOUSE | Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product] | DISRUPTION PHENOTYPE | Almost half of homozygous embryos mice for IHH died between 10.5 and 12.5 dpc. Also some lethality occurred in late gestation, most of the remaining embryos developed to term but died at birth, due to respiratory failure. Mutants display markedly reduced chondrocyte proliferation, maturation of chondrocytes at inappropriate position, and a failure of osteoblast development in endochondral bones. {ECO:0000269|PubMed:10465785}. |