| 16392 | P61372 | ISL1_MOUSE | Insulin gene enhancer protein ISL-1 (Islet-1) | DISRUPTION PHENOTYPE | Embryonic mutants exhibit growth retardation at approximately 9.5 dpc and die at approximately 10.5 dpc. Between 9.0 dpc and 9.5 dpc hearts are severely abnormal, appear misshapen and unlooped. Hearts are completely missing the outflow tract, right ventricle, and much of the atria (PubMed:14667410). Conditional mutants for retina expression show a decrease in several gene expression levels involved in the differentiation of retinal ganglion cells (RGC) (PubMed:24643061). {ECO:0000269|PubMed:14667410, ECO:0000269|PubMed:24643061}. |