| 16428 | Q03526 | ITK_MOUSE | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) (T-cell-specific kinase) | DISRUPTION PHENOTYPE | Mice display decreased mature thymocytes and elicit profound defect in CD4+ and CD8+ T-cell development (PubMed:8777721, PubMed:10213685, PubMed:16860760, PubMed:21036902). Additionally, they show a strong decrease of cytokine production in response to TCR receptor stimulation (PubMed:21036902). Impaired TCR-mediated calcium response in gamma-delta T-cells (PubMed:23562159). Loss of Vgamma2-positive immature thymocyte-specific transcriptomic profile, although there is no change to overall transcription factor expression levels (PubMed:23562159). Not required for the generation of IL17A expressing gamma-delta T-cells (PubMed:23562159). {ECO:0000269|PubMed:10213685, ECO:0000269|PubMed:16860760, ECO:0000269|PubMed:21036902, ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:8777721}. |