| 16558 | B1AVY7 | KI16B_MOUSE | Kinesin-like protein KIF16B | DISRUPTION PHENOTYPE | Embryonic death. Embryos are arrested at the blastocyst stage: the primitive endoderm and epiblast cannot be distinguished and appear as cell clumps resembling the inner cell mass (ICM) of the blastocyst. Embryos do not develop an epiblast epithelium and the uterine reaction appears to be incomplete. Development of the primitive endoderm and a basement membrane derived from it are severely affected in embryos at 4.5 dpc. {ECO:0000269|PubMed:21238925}. |