| 16572 | P33175 | KIF5A_MOUSE | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | DISRUPTION PHENOTYPE | Death shortly after birth. Neuron-specific deletion within the first 3 weeks after birth is lethal in 75% of animals. Surviving animals show accumulation of neurofilament proteins in neuronal soma, age-dependent sensory neuron degeneration, loss of large caliber axons, and hind limb paralysis with a stronger effect on sensory neurons compared with motor neurons. {ECO:0000269|PubMed:12682084}. |