| 16661 | P02535 | K1C10_MOUSE | Keratin, type I cytoskeletal 10 (56 kDa cytokeratin) (Cytokeratin-10) (CK-10) (Keratin, type I cytoskeletal 59 kDa) (Keratin-10) (K10) | DISRUPTION PHENOTYPE | Mice are viable and display no differences in size and body weight (PubMed:26603179). Show acanthosis, hyperkeratosis and scaling of the stratum corneum in plantar skin (PubMed:26603179). Increase in the number of epidermal cell layers and a decrease in the abundance of cytoplasmic keratin filament bundles in suprabasal cells (PubMed:24751727). Large keratohyalin granules of various shapes are evident in the upper suprabasal cells (PubMed:24751727). KRT2 aggregates form in the cytoplasm of keratinocytes (PubMed:24751727). Show no epidermal aberrations of the footpads (PubMed:26603179). Double knockout mice of KRT10 and KRT2 are viable and display no differences in size and body weight (PubMed:26603179). Show a more severe epidermis phenotype as in single KRT10 knockout mice (PubMed:24751727, PubMed:26603179). {ECO:0000269|PubMed:24751727, ECO:0000269|PubMed:26603179}. |