| 16681 | Q3TTY5 | K22E_MOUSE | Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2) | DISRUPTION PHENOTYPE | Mice are viable and display no differences in size and body weight (PubMed:24751727, PubMed:26603179). Scaly skin and increased pigmentation on ears and hyperkeratotic calluses on the soles and toe pads within 6 weeks of birth (PubMed:24751727, PubMed:26603179). Prominent acanthosis, orthokeratotic hyperkeratosis in the epidermis of the ear and to a lesser extent in the epidermis of the tail and the palm skin caused by an increase in cell proliferation and thicker granular layer (PubMed:24751727). Keratinocyte differentiation is disorganized, large coalescent granules are accumulated, and cytolysis is evidence in the ear skin (PubMed:24751727). Increase in defective corneocytes and an increase in transepidermal water loss in ear skin (PubMed:24751727). Suprabasal keratinocytes contain distinct spongy clumps of Krt10 filaments (PubMed:24751727). Increase in Tslp and Il18 expression, and abundance of T-cells and mast cells in ear skin (PubMed:24751727). Increase in expression of Krt1, Krt10, Krt16, Flg and Loricrin in the ear epidermis (PubMed:24751727). Krt1, Krt5, Krt10, Krt16, Flg and Loricrin all show disordered localization within the ear epidermis (PubMed:24751727). Krt10 specifically show aggregation within the cytoplasm in epidermal cells of the ear (PubMed:24751727). Show no epidermal aberrations of the footpads (PubMed:26603179). Double knockout mice of KRT2 and KRT10 are viable and display no differences in size and body weight (PubMed:26603179). Show a more severe plantar epidermis phenotype as in single KRT2 knockout mice (PubMed:26603179). {ECO:0000269|PubMed:24751727, ECO:0000269|PubMed:26603179}. |