| 16768 | Q61790 | LAG3_MOUSE | Lymphocyte activation gene 3 protein (LAG-3) (Activation-induced cytidine deaminase-linked autoimmunity protein) (Aida) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)] | DISRUPTION PHENOTYPE | Mice develop normally but show minor defects in the natural killer (NK) cells (PubMed:8602528). They are however prone to development of autoimmune diseases, such as autoimmune diabetes on a permissive genetic background (PubMed:21300912, PubMed:21873518). Knockout NOD mice exhibit accelerated, invasive insulitis, corresponding to increased CD4(+) and CD8(+) T-cell islet infiltration and intraislet proliferation (PubMed:21873518). T-cells display a delay in cell cycle arrest following stimulation with the superantigen staphylococcal enterotoxin-B resulting in increased T-cell expansion and splenomegaly (PubMed:15100286). Mice lacking both Lag3 and Pdcd1/PD-1 die of severe myocarditis before 10 weeks of age in BALB/c mice (PubMed:21300912). {ECO:0000269|PubMed:15100286, ECO:0000269|PubMed:21300912, ECO:0000269|PubMed:21873518, ECO:0000269|PubMed:8602528}. |