Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:16911
  • Symbol:Lmo4
  • Description:LIM domain only 4
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Gene ID Entry Entry Name Protein Name Type Information
16911 P61969 LMO4_MOUSE LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4) DISRUPTION PHENOTYPE Overall patterning of ventral spinal cord neurons is normal at 12.5 dpc and 14.5 dpc, but there are additional ectopic V2 interneurons (V2-INs) at all axial levels of the spinal cord; phenotype exacerbated in an MNX1 mutant background (PubMed:18539116). In an MNX1 mutant background, genes typically expressed in V2-INs expressed ectopically in motor neurons (MNs) (PubMed:18539116). Abnormal guidance of motor axons in an MNX1 mutant background (PubMed:18539116). {ECO:0000269|PubMed:18539116}.