| 16973 | Q91VN0 | LRP5_MOUSE | Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) | DISRUPTION PHENOTYPE | Mice exhibit decreased osteoblast proliferation, developing low bone mass postnatally. Also display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. Mutant animals exhibit a loss of middle phalanx ossification at 18.5 dpc. LRP5 and LRP6 double null mutants are more severely affected. Embryos arrest prior to mid-gestation. {ECO:0000269|PubMed:11956231, ECO:0000269|PubMed:15142971}. |