| 171469 | Q99JG2 | G37L1_MOUSE | G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) | DISRUPTION PHENOTYPE | Premature down-regulation of proliferation of cerebellar granule neuron precursors in postnatal mice, precocious maturation of Bergmann glia and Purkinje neurons, precocious juvenile motor abilities, and improved adult motor learning and coordination (PubMed:24062445). Early activation of the Shh pathway with increased levels of Shh, Smo and Ptch1 earlier in postnatal development than in wild-type mice (PubMed:24062445). Increased aortic diastolic, mean arterial and pulse pressures in females but not in males (PubMed:29625592). Males develop exacerbated left ventricular hypertrophy and evidence of heart failure when challenged with short-term angiotensin-2 infusion while females are protected from cardiac fibrosis (PubMed:29625592). Increased susceptibility to induced seizures (PubMed:28688853). Reduced signaling in the cerebellum as indicated by significantly less cAMP production (PubMed:27072655). No effect on the input resistance or resting potential of astrocytes or neurons (PubMed:28795439). Neuronal death is increased by 40% in an in vitro model of ischemia (PubMed:28795439). {ECO:0000269|PubMed:24062445, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853, ECO:0000269|PubMed:28795439, ECO:0000269|PubMed:29625592}. |