| 17356 | Q9QZQ1 | AFAD_MOUSE | Afadin (Afadin adherens junction formation factor) (Protein Af-6) | DISRUPTION PHENOTYPE | Mice show developmental defects at stages during and after gastrulation, including disorganization of the ectoderm, impaired migration of the mesoderm and loss of somites and other structures derived from both the ectoderm and mesoderm. Cell-cell adherens juntions and tight junctions are improperly organized in the ectoderm-derived cells. No redundancy exists in the function of afadin during gastrulation. {ECO:0000269|PubMed:10477764}. |