| 18002 | P29595 | NEDD8_MOUSE | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) | DISRUPTION PHENOTYPE | Mice die in utero at the periimplantation stage due to impaired cell cycle progression (PubMed:11696557). Embryos show selective apoptosis of the inner cell mass but not of trophoblastic cells (PubMed:11696557). However, trophoblastic cells do not enter the S phase of the endoreduplication cycle (PubMed:11696557). {ECO:0000269|PubMed:11696557}. |