Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18212
  • Symbol:Ntrk2
  • Description:neurotrophic tyrosine kinase, receptor, type 2
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Gene ID Entry Entry Name Protein Name Type Information
18212 P15209 NTRK2_MOUSE BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB/GP95-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) DISRUPTION PHENOTYPE Mice lacking isoform GP145-TRKB, the catalytic isoform, do not display feeding activity and die at P1. This is associated neuronal deficiencies in the central and the peripheral nervous systems. {ECO:0000269|PubMed:8402890}.