| 18389 | P35377 | OPRX_MOUSE | Nociceptin receptor (K3 opiate receptor) (Kappa-type 3 opioid receptor) (KOR-3) (ORGC) (Orphanin FQ receptor) | DISRUPTION PHENOTYPE | Mutant mice do not show altered basal nociception, but are no longer susceptible to modulation of nociception by the neuropeptide nociceptin. Contrary to wild-type, they do not show reduced locomotion in response to the neuropeptide nociceptin. In addition, mutant mice show subtle hearing defects. {ECO:0000269|PubMed:12217419, ECO:0000269|PubMed:12814369, ECO:0000269|PubMed:9155012}. |