Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18514
  • Symbol:Pbx1
  • Description:pre B cell leukemia homeobox 1
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Gene ID Entry Entry Name Protein Name Type Information
18514 P41778 PBX1_MOUSE Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) DISRUPTION PHENOTYPE Conditional knockout in hematopoietic cells leads to a reduction in the number of natural killer cell-committed progenitors in bone marrow, decreases the number of natural killer cells in bone marrow and spleen and reduces NFIL3 expression in bone marrow and splenic natural killer cells. {ECO:0000269|PubMed:32190943}.