Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18742
  • Symbol:Pitx3
  • Description:paired-like homeodomain transcription factor 3
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Gene ID Entry Entry Name Protein Name Type Information
18742 O35160 PITX3_MOUSE Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3) DISRUPTION PHENOTYPE Mice show loss of nascent substantia nigra dopaminergic neurons at the beginning of their final differentiation and a loss of tyrosine hydroxylase (TH) expression specifically in the substantia nigra neurons. {ECO:0000269|PubMed:15950611}.