| 18751 | P68404 | KPCB_MOUSE | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | DISRUPTION PHENOTYPE | Mice develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B-cells similar to X-linked immunodeficiency (Xid). Mice are unable to activate NF-kappa-B and promote cell survival in B-cells upon BCR signaling, or even in mast cells. B-cells fail to recruit the I-kappa-B kinase (IKK) complex into lipid rafts, activate IKK, degrade I-kappa-B or up-regulate NF-kappa-B-dependent survival signals. Moreover, mutant animals are hyperphagic and exhibit higher food intake and reduced feed efficiency versus wild type. Mice are considerably leaner and display markedly decreased size of white fat depots. Triglyceride content in the liver and skeletal muscle is also significantly low. {ECO:0000269|PubMed:12118249, ECO:0000269|PubMed:17962198, ECO:0000269|PubMed:8670417}. |