Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18752
  • Symbol:Prkcg
  • Description:protein kinase C, gamma
Export (tab separated) Export to Excel
Gene ID Entry Entry Name Protein Name Type Information
18752 P63318 KPCG_MOUSE Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) DISRUPTION PHENOTYPE Mice exhibit impaired motor coordination due to the inability to eliminate multiple climbing fibers during innervation of Purkinje cells. 40% of Purkinje cells are still innervated by multiple climbing fibers. Exhibit food-anticipatory activity comparable to that of wild type mice but they do not reduce their late night activity or adapt their food intake amount to restricted feeding as efficiently as wild type mice. {ECO:0000269|PubMed:23185022, ECO:0000269|PubMed:8548809}.