| 18762 | Q02956 | KPCZ_MOUSE | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | DISRUPTION PHENOTYPE | No visible phenotype (PubMed:23283171). Reduced anxiety-like behavior in males (PubMed:23283171). Does not affect long term memory maintenance (PubMed:23283171, PubMed:27187150). However, when the conditions during the establishment of memory are more demanding, spatial long term memory maintenance is slightly affected (PubMed:27187150). Up-regulation of PRKCI/PKCiota protein levels following induction of synaptic long term potentiation abnormally persist. This compensatory mechanism is responsible for the lack of defect in long term memory maintenance in absence of isoform 1 and isoform 2 (PubMed:27187150). Isoform 2: RNAi-mediated knockdown prevents late synaptic long term potentiation and spatial long term memory (PubMed:27187150). {ECO:0000269|PubMed:23283171, ECO:0000269|PubMed:27187150}. |