Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:19091
  • Symbol:Prkg1
  • Description:protein kinase, cGMP-dependent, type I
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Gene ID Entry Entry Name Protein Name Type Information
19091 P0C605 KGP1_MOUSE cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) DISRUPTION PHENOTYPE Leads to premature death at approximately 6 weeks of age, presumably due to smooth muscle dysfunction. These mice show multiple defects including impaired smooth muscle relaxation, disturbed gastrointestinal motility and enhanced platelet adhesion. {ECO:0000269|PubMed:10209042, ECO:0000269|PubMed:9606187}.