| 19263 | B2RU80 | PTPRB_MOUSE | Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) | DISRUPTION PHENOTYPE | Mice show severe cardiovascular defects and embryonic lethality by 10 dpc. Vasculogenesis occurs normally however, angiogenesis is abnormal. Angiogenic defects are most pronounced in the yolk sac and include a complete failure to elaborate the primitive vascular scaffold into higher-order branched arteries, veins, and capillaries. {ECO:0000269|PubMed:17360632}. |