| 19876 | O89026 | ROBO1_MOUSE | Roundabout homolog 1 | DISRUPTION PHENOTYPE | Mice show defects in commissural axon guidance in spinal cord including midline recrossing and an altered lateral and ventral funiculi projection. The phenotype resembles that of a SLIT1;SLIT2;SLIT3 triple mutant. They also mimick a naturally occurring human homozygous deletion mutant detected in a small lung cancer cell line, frequently die at birth by respiratory failure with accompanying abnormal lung histology. Surviving mice develop bronchial hyperplasia. {ECO:0000269|PubMed:11734623}. |