Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:19877
  • Symbol:Rock1
  • Description:Rho-associated coiled-coil containing protein kinase 1
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Gene ID Entry Entry Name Protein Name Type Information
19877 P70335 ROCK1_MOUSE Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) DISRUPTION PHENOTYPE Mice exhibit both EOB (eyes open at birth) and omphalocele phenotypes as a result of disorganization of actomyosin cables in the eyelid epithelium and defective actin assembly in the umbilical ring. {ECO:0000269|PubMed:15753128}.