Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:20379
  • Symbol:Sfrp4
  • Description:secreted frizzled-related protein 4
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Gene ID Entry Entry Name Protein Name Type Information
20379 Q9Z1N6 SFRP4_MOUSE Secreted frizzled-related sequence protein 4 (FRP-4) (sFRP-4) DISRUPTION PHENOTYPE Mice laking Sfrp4 have increased trabecular bone, reduced cortical-bone thickness, and failure of bone modeling during growth, resulting in wider bones with thinner and mechanically inadequate cortexes. {ECO:0000269|PubMed:27355534}.