Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:20563
  • Symbol:Slit2
  • Description:slit guidance ligand 2
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Gene ID Entry Entry Name Protein Name Type Information
20563 Q9R1B9 SLIT2_MOUSE Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] DISRUPTION PHENOTYPE Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT). {ECO:0000269|PubMed:12097499}.