| 20612 | Q62230 | SN_MOUSE | Sialoadhesin (Sheep erythrocyte receptor) (SER) (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) | DISRUPTION PHENOTYPE | SIGLEC1-deficient mice are viable, display no gross developmental abnormalities, and exhibit only subtle changes in B- and T-cell populations (PubMed:16449664). However, they are significantly more susceptible to bacterial infection than WT (PubMed:24788876). In addition, serum IgM and IgG amounts are greatly reduced in mutant mice (PubMed:16449664, PubMed:24788876). {ECO:0000269|PubMed:16449664, ECO:0000269|PubMed:24788876}. |