Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:20620
  • Symbol:Plk2
  • Description:polo like kinase 2
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Gene ID Entry Entry Name Protein Name Type Information
20620 P53351 PLK2_MOUSE Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase) DISRUPTION PHENOTYPE Embryos display a delay in skeletal development and retarded growth. Embryonic fibroblasts proliferated slowly and displayed a delayed entry into S phase. Mice display loss of dendritic spines and impaired memory formation. {ECO:0000269|PubMed:12972611, ECO:0000269|PubMed:21382555}.