| 20787 | Q9WTN3 | SRBP1_MOUSE | Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | DISRUPTION PHENOTYPE | Mice show high embryonic lethality around day 11 dpc (PubMed:9329978). Surviving mice show a 2-3-fold increase in processed Srebpf2 protein in liver nuclei, 3-fold increase in cholesterol synthesis and 50% increase in cholesterol content of the liver (PubMed:9329978). {ECO:0000269|PubMed:9329978}.; DISRUPTION PHENOTYPE: [Isoform SREBP-1A]: Mice lacking isoform SREBP-1A are resistant to pro-inflammatory toxic shock (PubMed:21531336). Macrophages challenged with bacterial lipopolysaccharide fail to activate lipogenesis as well as hallmarks of inflammasome functions, activation of caspase-1 and secretion of IL1B (PubMed:21531336). {ECO:0000269|PubMed:21531336}.; DISRUPTION PHENOTYPE: [Isoform SREBP-1C]: Mice lacking isoform SREBP-1C show a lack of up-regulation of several lipogenic enzymes in response to high insulin or LXR activation. {ECO:0000269|PubMed:11782483}. |