| 209039 | Q8CGB6 | TENS2_MOUSE | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | DISRUPTION PHENOTYPE | Glomerular defects during postnatal nephrogenesis including severe glomerular basement membrane (GBM) thickening, effacement of podocyte foot processes, and mesangial expansion and sclerosis (PubMed:32390516). Ectopic expression of laminin LAMA2 in the GBM followed by the accumulation of immature laminin components (PubMed:32390516). Decreased adhesion of podocytes to the GBM (PubMed:32390516). {ECO:0000269|PubMed:32390516}. |